| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-2 catalytic subunit |
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| Ligand | BDBM50189828 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_367108 (CHEMBL863672) |
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| IC50 | 190±n/a nM |
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| Citation |  Shirasaki, Y; Nakamura, M; Yamaguchi, M; Miyashita, H; Sakai, O; Inoue, J Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives. J Med Chem49:3926-32 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-2 catalytic subunit |
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| Name: | Calpain-2 catalytic subunit |
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| Synonyms: | 3.4.22.53 | CAN2_PIG | CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain |
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| Type: | n/a |
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| Mol. Mass.: | 37789.71 |
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| Organism: | Sus scrofa |
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| Description: | n/a |
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| Residue: | 324 |
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| Sequence: | YPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEV
PEELTGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGD
FCIRVFSEKKADYQVVDDEIEADLEENDASEDDIDDGFRRLFAQLAGEDAEISAFELQTI
LRRVLAKRQDIKSDGFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQKIYREIDV
DRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFRIS
KQLDSENTGTIELDLISWLCFSVL
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| BDBM50189828 |
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| n/a |
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| Name | BDBM50189828 |
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| Synonyms: | 1-((S)-1-((3S)-2-hydroxy-tetrahydrofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-3-phenylthiourea | CHEMBL207440 | SNJ-1715 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25N3O3S |
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| Mol. Mass. | 351.464 |
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| SMILES | CC(C)C[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O |
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| Structure | 
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