| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NADPH oxidase 4 |
|---|
| Ligand | BDBM50606914 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2261583 (CHEMBL5216594) |
|---|
| IC50 | 680±n/a nM |
|---|
| Citation |  Shahari, MSB; Dolzhenko, AV A closer look at N Eur J Med Chem241:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NADPH oxidase 4 |
|---|
| Name: | NADPH oxidase 4 |
|---|
| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66954.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_792879 |
|---|
| Residue: | 578 |
|---|
| Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
|
|
|
|---|
| BDBM50606914 |
|---|
| n/a |
|---|
| Name | BDBM50606914 |
|---|
| Synonyms: | CHEMBL5218591 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27N7 |
|---|
| Mol. Mass. | 389.4967 |
|---|
| SMILES | Cc1ccc(cc1)N1CCN(CC1)c1nc(N)nc(Nc2ccc(C)c(C)c2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
