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TargetCarbonic anhydrase 1
LigandBDBM50190240
Substrate/Competitorn/a
Meas. Tech.ChEMBL_400479
Ki 14200±n/a nM
Citation Slawinski FSlawinski JKornicka ABrzozowski ZPomarnacka EInnocenti ASlawinski ASlawinski CT Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg Med Chem Lett 16:4846-51 (2006) [PubMed]  Article
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Carbonic anhydrase 1
Name:Carbonic anhydrase
Synonyms:CA-I | CAB | Carbonate dehydratase I | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:Enzyme
Mol. Mass.:28873.37
Organism:Homo sapiens (Human)
Description:P00915
Residue:261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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BDBM50190240
n/a
NameBDBM50190240
Synonyms:4-chloro-2-(1-hydrazinocarbonyl-ethanesulfonyl)-5-methyl-benzenesulfonamide | CHEMBL215276
TypeSmall organic molecule
Emp. Form.C10H14ClN3O5S2
Mol. Mass.355.818
SMILESCC(C(=O)NN)S(=O)(=O)c1cc(Cl)c(C)cc1S(N)(=O)=O
Structure
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