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TargetCarbonic anhydrase 12
LigandBDBM50190243
Substrate/Competitorn/a
Meas. Tech.ChEMBL_400482
Ki 1970±n/a nM
Citation Slawinski FSlawinski JKornicka ABrzozowski ZPomarnacka EInnocenti ASlawinski ASlawinski CT Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg Med Chem Lett 16:4846-51 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase
Synonyms:CA-XII | Carbonate dehydratase XII | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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  Blast E-value cutoff:
BDBM50190243
n/a
NameBDBM50190243
Synonyms:6-{[7-(aminosulfonyl)-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-6-yl]dithio}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide | CHEMBL215776
TypeSmall organic molecule
Emp. Form.C14H16N6O8S6
Mol. Mass.588.702
SMILESNS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1SSc1cc2NCNS(=O)(=O)c2cc1S(N)(=O)=O
Structure
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