| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor |
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| Ligand | BDBM50190352 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_405015 (CHEMBL868058) |
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| IC50 | 146±n/a nM |
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| Citation |  Wildonger, KJ; Ratcliffe, RW; Mosley, RT; Hammond, ML; Birzin, ET; Rohrer, SP Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands. Bioorg Med Chem Lett16:4462-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor |
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| Name: | Estrogen receptor |
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| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 66230.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372 |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM50190352 |
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| n/a |
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| Name | BDBM50190352 |
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| Synonyms: | (1S,12R,15R)-15-ethyl-5-hydroxy-10-methyltetracyclo[10.3.1.0^{1,9}.0^{3,8}]hexadeca-3,5,7,9-tetraen-11-one | CHEMBL213337 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22O2 |
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| Mol. Mass. | 282.3768 |
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| SMILES | CC[C@@H]1CC[C@@H]2C[C@]11Cc3cc(O)ccc3C1=C(C)C2=O |t:19| |
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| Structure | 
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