| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit gamma |
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| Ligand | BDBM50405340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2265085 |
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| Ki | 955000±n/a nM |
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| Citation |  Müller, J; Klein, R; Tarkhanova, O; Gryniukova, A; Borysko, P; Merkl, S; Ruf, M; Neumann, A; Gastreich, M; Moroz, YS; Klebe, G; Glinca, S Magnet for the Needle in Haystack: "Crystal Structure First" Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces. J Med Chem65:15663-15678 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit gamma |
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| Name: | cAMP-dependent protein kinase catalytic subunit gamma |
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| Synonyms: | KAPCG_HUMAN | PKA C-gamma | PRKACG | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic subunit gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40442.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104720 |
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| Residue: | 351 |
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| Sequence: | MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML
VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV
MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY
LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY
ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
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| BDBM50405340 |
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| n/a |
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| Name | BDBM50405340 |
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| Synonyms: | CHEMBL5276693 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N3O |
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| Mol. Mass. | 279.3364 |
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| SMILES | Nc1ccc(cc1C#N)-c1cccc(c1)C1COCCN1 |
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| Structure | 
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