Ki Summary

Reaction Details

Report a problem with these data

Target

Wee1-like protein kinase

Ligand

BDBM50192427

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_379935 (CHEMBL864855)

IC50

35±n/a nM

Citation

Palmer, BD; Thompson, AM; Booth, RJ; Dobrusin, EM; Kraker, AJ; Lee, HH; Lunney, EA; Mitchell, LH; Ortwine, DF; Smaill, JB; Swan, LM; Denny, WA 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem49:4896-911 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Wee1-like protein kinase

Name:

Wee1-like protein kinase

Synonyms:

Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN

Type:

PROTEIN

Mol. Mass.:

71599.12

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1445054

Residue:

646

Sequence:

MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY

BDBM50192427

n/a

Name

BDBM50192427

Synonyms:

4-(2,6-dibromophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL378067

Type

Small organic molecule

Emp. Form.

C20H10Br2N2O3

Mol. Mass.

486.113

SMILES

Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Br)cccc1Br |(7.66,-44.93,;8.99,-45.7,;8.99,-47.24,;10.32,-48.02,;11.65,-47.25,;13.13,-47.72,;14.03,-46.47,;15.57,-46.31,;16.2,-44.9,;15.28,-43.65,;15.6,-42.15,;17.01,-41.53,;14.27,-41.38,;13.13,-42.4,;11.63,-42.08,;13.75,-43.81,;13.13,-45.22,;11.65,-45.69,;10.32,-44.93,;17.72,-44.74,;18.63,-45.98,;18.01,-47.39,;20.16,-45.82,;20.78,-44.41,;19.87,-43.16,;18.34,-43.33,;17.43,-42.09,)|

Structure