| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor |
|---|
| Ligand | BDBM50184071 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_402775 (CHEMBL908626) |
|---|
| Ki | 48±n/a nM |
|---|
| Citation |  Burgey, CS; Stump, CA; Nguyen, DN; Deng, JZ; Quigley, AG; Norton, BR; Bell, IM; Mosser, SD; Salvatore, CA; Rutledge, RZ; Kane, SA; Koblan, KS; Vacca, JP; Graham, SL; Williams, TM Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine. Bioorg Med Chem Lett16:5052-6 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcitonin gene-related peptide type 1 receptor |
|---|
| Name: | Calcitonin gene-related peptide type 1 receptor |
|---|
| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52980.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16602 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
|
|
|
|---|
| BDBM50184071 |
|---|
| n/a |
|---|
| Name | BDBM50184071 |
|---|
| Synonyms: | (R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)piperidine-1-carboxamide | CHEMBL424864 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H29F3N6O3 |
|---|
| Mol. Mass. | 590.5956 |
|---|
| SMILES | FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |c:13| |
|---|
| Structure | 
|
|---|
Search and Browse
