Reaction Details |
| Report a problem with these data |
Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
---|
Ligand | BDBM50192671 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_422275 (CHEMBL855995) |
---|
IC50 | >100000±n/a nM |
---|
Citation | Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements. Bioorg Med Chem Lett16:5408-13 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
11-beta-hydroxysteroid dehydrogenase type 2 |
---|
Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase type 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_MOUSE | Hsd11b2 | Hsd11k | NAD-dependent 11-beta-hydroxysteroid dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 42201.46 |
Organism: | Mus musculus (mouse) |
Description: | Purified recombinant mouse 11beta-HSD2. |
Residue: | 386 |
Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVV
LAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPG
ALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELS
PVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIA
LLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYI
EHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRR
CFLQNFFINHLLPRALRPGQHGPAPA
|
|
|
BDBM50192671 |
---|
n/a |
---|
Name | BDBM50192671 |
Synonyms: | 2-(4-chlorophenoxy)-N-(5-cyanocyclooctyl)-2-methylpropanamide | CHEMBL387010 |
Type | Small organic molecule |
Emp. Form. | C19H25ClN2O2 |
Mol. Mass. | 348.867 |
SMILES | CC(C)(Oc1ccc(Cl)cc1)C(=O)NC1CCCC(CCC1)C#N |
Structure |
|