Reaction Details |
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Target | Synaptic vesicular amine transporter |
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Ligand | BDBM50192902 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_404073 (CHEMBL909739) |
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Ki | 28±n/a nM |
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Citation | Zheng, G; Horton, DB; Deaciuc, AG; Dwoskin, LP; Crooks, PA Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett16:5018-21 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Synaptic vesicular amine transporter |
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Name: | Synaptic vesicular amine transporter |
Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
Type: | Protein |
Mol. Mass.: | 55689.58 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q01827 |
Residue: | 515 |
Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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BDBM50192902 |
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n/a |
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Name | BDBM50192902 |
Synonyms: | 2-ethyl-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol | CHEMBL213814 | Ro-4-1284 |
Type | Small organic molecule |
Emp. Form. | C21H33NO3 |
Mol. Mass. | 347.4916 |
SMILES | CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C |
Structure |
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