Reaction Details |
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Target | Cathepsin B |
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Ligand | BDBM50193494 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_386233 (CHEMBL870447) |
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Ki | 1480±n/a nM |
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Citation | Korukonda, R; Guan, N; Dalton, JT; Liu, J; Donkor, IO Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides. J Med Chem49:5282-90 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin B |
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Name: | Cathepsin B |
Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
Type: | Enzyme |
Mol. Mass.: | 37819.69 |
Organism: | Homo sapiens (Human) |
Description: | gi_63102437 |
Residue: | 339 |
Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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BDBM50193494 |
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n/a |
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Name | BDBM50193494 |
Synonyms: | (R)-1-(4-methoxyphenylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide | CHEMBL211105 |
Type | Small organic molecule |
Emp. Form. | C21H24N2O5S |
Mol. Mass. | 416.491 |
SMILES | COc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]1C(=O)NC(Cc1ccccc1)C=O |
Structure |
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