| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
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| Ligand | BDBM50193773 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_424084 (CHEMBL855087) |
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| IC50 | 12.4±n/a nM |
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| Citation |  Watson, PS; Jiang, B; Harrison, K; Asakawa, N; Welch, PK; Covington, M; Stowell, NC; Wadman, EA; Davies, P; Solomon, KA; Newton, RC; Trainor, GL; Friedman, SM; Decicco, CP; Ko, SS 2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity. Bioorg Med Chem Lett16:5695-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 3 |
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| Name: | C-C chemokine receptor type 3 |
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| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41053.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51677 |
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| Residue: | 355 |
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| Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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| BDBM50193773 |
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| n/a |
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| Name | BDBM50193773 |
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| Synonyms: | 1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2,2-difluoroethyl)piperidin-2-yl)propyl)-3-(3,5-diacetylphenyl)urea | CHEMBL386493 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34F3N3O3 |
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| Mol. Mass. | 517.5831 |
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| SMILES | CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)F)cc(c1)C(C)=O |
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| Structure | 
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