| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50194181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_391996 (CHEMBL871066) |
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| IC50 | 4400±n/a nM |
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| Citation |  Casanova, E; Hernandez, AI; Priego, EM; Liekens, S; Camarasa, MJ; Balzarini, J; Pérez-Pérez, MJ 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem49:5562-70 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49948.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
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| Residue: | 482 |
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| Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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| BDBM50194181 |
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| n/a |
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| Name | BDBM50194181 |
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| Synonyms: | 1-(cyclohexyl)methyl-5'-O-tritylinosine | CHEMBL211259 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H38N4O5 |
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| Mol. Mass. | 606.7107 |
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| SMILES | O[C@@H]1[C@@H](COC(c2ccccc2)(c2ccccc2)c2ccccc2)O[C@H]([C@@H]1O)n1cnc2c1ncn(CC1CCCCC1)c2=O |
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| Structure | 
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