| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 8 |
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| Ligand | BDBM50441212 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2269397 |
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| IC50 | 120±n/a nM |
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| Citation |  Cuffaro, D; Camodeca, C; Tuccinardi, T; Ciccone, L; Bartsch, JW; Kellermann, T; Cook, L; Nuti, E; Rossello, A Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med Chem Lett12:1787-1793 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 8 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 8 |
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| Synonyms: | ADAM8 | ADAM8_HUMAN | MS2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88789.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_492660 |
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| Residue: | 824 |
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| Sequence: | MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYV
LGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAAS
LSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP
RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKL
NFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTT
VGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAG
RCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGE
QCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCD
GRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCK
ASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKG
RCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVV
VLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPS
RGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFA
PPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP
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| BDBM50441212 |
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| n/a |
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| Name | BDBM50441212 |
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| Synonyms: | CHEMBL2431028 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22Br2N4O6S |
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| Mol. Mass. | 594.274 |
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| SMILES | NC(=O)NCCC[C@@H](NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1)C(=O)NO |r| |
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| Structure | 
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