| Reaction Details |
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 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Ligand | BDBM50095995 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2270637 |
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| Ki | 94±n/a nM |
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| Citation |  Wang, Y; Qu, C; Liu, T; Wang, C PFKFB3 inhibitors as potential anticancer agents: Mechanisms of action, current developments, and structure-activity relationships. Eur J Med Chem203:0 (2020) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Synonyms: | 6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) | 6PF-2-K/Fru-2,6-P2ase 3 | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme | F263_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 3 | PFKFB3 | Renal carcinoma antigen NY-REN-56 | iPFK-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59620.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16875 |
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| Residue: | 520 |
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| Sequence: | MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
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| BDBM50095995 |
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| n/a |
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| Name | BDBM50095995 |
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| Synonyms: | 7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER | 7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester | CHEMBL155103 | ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10O5 |
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| Mol. Mass. | 234.2048 |
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| SMILES | CCOC(=O)c1cc2ccc(O)cc2oc1=O |
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| Structure | 
|
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