| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM50054600 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_424735 (CHEMBL907887) |
|---|
| IC50 | 23±n/a nM |
|---|
| Citation |  Kuo, PY; Shie, TL; Chen, YS; Lai, JT; Yang, DY Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl derivatives. Bioorg Med Chem Lett16:6024-7 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | DHOdehase | Dhodh | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial precursor | Dihydroorotate oxidase | PYRD_RAT |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42672.97 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | The enzyme assay was performed with the histidine-tagged enzyme without cleavage of the tag. |
|---|
| Residue: | 395 |
|---|
| Sequence: | MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVR
VTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGIN
LGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQER
DALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIF
LGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
|
|
|
|---|
| BDBM50054600 |
|---|
| n/a |
|---|
| Name | BDBM50054600 |
|---|
| Synonyms: | (Z)-2-Cyano-3-hydroxy-penta-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide | 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide | CHEMBL141047 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H9F3N2O2 |
|---|
| Mol. Mass. | 282.218 |
|---|
| SMILES | FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C=C)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
