Ki Summary

Reaction Details

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Target

11-beta-hydroxysteroid dehydrogenase 1

Ligand

BDBM50195488

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_425005 (CHEMBL912530)

17±n/a nM

Citation

Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett16:6241-5 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

11-beta-hydroxysteroid dehydrogenase 1

Name:

11-beta-hydroxysteroid dehydrogenase 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

31889.48

Organism:

Rattus norvegicus (rat)

Description:

P16232

Residue:

288

Sequence:

MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN

BDBM50195488

n/a

Name

BDBM50195488

Synonyms:

CHEMBL374487 | N-((1s,4s)-4-((2-(dimethylamino)ethyl)carbamoyl)cyclohexyl)-4-amino-3,5-dichloro-N-cyclopropylbenzamide

Type

Small organic molecule

Emp. Form.

C21H30Cl2N4O2

Mol. Mass.

441.395

SMILES

CN(C)CCNC(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 |wU:8.7,11.14,(26.28,-50.13,;24.95,-49.36,;23.61,-50.12,;24.96,-47.82,;23.62,-47.04,;23.63,-45.5,;22.3,-44.73,;20.96,-45.5,;22.3,-43.19,;23.64,-42.42,;23.65,-40.88,;22.31,-40.11,;20.98,-40.88,;20.97,-42.41,;22.31,-38.57,;20.98,-37.8,;20.21,-36.47,;19.44,-37.8,;23.65,-37.8,;23.65,-36.26,;24.98,-38.57,;26.31,-37.8,;27.64,-38.56,;28.97,-37.79,;27.65,-40.11,;28.98,-40.88,;26.31,-40.89,;26.31,-42.43,;24.98,-40.11,)|

Structure