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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50195490 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_425005 (CHEMBL912530) | ||
| Ki | 20±n/a nM | ||
| Citation |  Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett16:6241-5 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 31889.48 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | P16232 | ||
| Residue: | 288 | ||
| Sequence: |
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| BDBM50195490 | |||
| n/a | |||
| Name | BDBM50195490 | ||
| Synonyms: | 2-((1s,4s)-4-(4-amino-3,5-dichloro-N-cyclopropylbenzamido)cyclohexanecarboxamido)acetic acid | CHEMBL374318 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H23Cl2N3O4 | ||
| Mol. Mass. | 428.31 | ||
| SMILES | Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCC(O)=O |wU:15.16,18.23,(25.2,-26.37,;23.86,-25.6,;23.86,-24.05,;25.19,-23.27,;22.52,-23.29,;21.19,-24.06,;21.19,-25.6,;22.52,-26.37,;22.52,-27.91,;19.86,-23.29,;19.86,-21.75,;18.52,-24.06,;17.19,-23.29,;16.42,-21.95,;15.65,-23.29,;18.52,-25.6,;19.86,-26.36,;19.85,-27.91,;18.52,-28.68,;17.19,-27.9,;17.19,-26.37,;18.51,-30.22,;17.17,-30.98,;19.84,-30.99,;19.84,-32.53,;21.17,-33.31,;21.16,-34.85,;22.5,-32.54,)| | ||
| Structure | 
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