Ki Summary

Reaction Details

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Target

11-beta-hydroxysteroid dehydrogenase 1

Ligand

BDBM50195503

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_425005 (CHEMBL912530)

39±n/a nM

Citation

Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett16:6241-5 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

11-beta-hydroxysteroid dehydrogenase 1

Name:

11-beta-hydroxysteroid dehydrogenase 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

31889.48

Organism:

Rattus norvegicus (rat)

Description:

P16232

Residue:

288

Sequence:

MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN

BDBM50195503

n/a

Name

BDBM50195503

Synonyms:

4-amino-N-((1s,4s)-4-(benzylcarbamoyl)cyclohexyl)-3,5-dichloro-N-cyclopropylbenzamide | CHEMBL222510

Type

Small organic molecule

Emp. Form.

C24H27Cl2N3O2

Mol. Mass.

460.396

SMILES

Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCc1ccccc1 |wU:18.23,15.16,(32.12,-16.53,;30.78,-15.76,;30.78,-14.21,;32.11,-13.44,;29.44,-13.45,;28.11,-14.22,;28.11,-15.76,;29.45,-16.53,;29.45,-18.07,;26.78,-13.45,;26.78,-11.91,;25.45,-14.22,;24.11,-13.45,;23.35,-12.11,;22.58,-13.45,;25.45,-15.76,;26.78,-16.53,;26.78,-18.07,;25.44,-18.84,;24.11,-18.06,;24.11,-16.53,;25.43,-20.38,;24.1,-21.14,;26.76,-21.15,;26.76,-22.69,;28.09,-23.47,;28.07,-25.01,;29.4,-25.78,;30.74,-25.02,;30.74,-23.47,;29.41,-22.7,)|

Structure