| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase |
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| Ligand | BDBM50195618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_416719 (CHEMBL909985) |
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| IC50 | 79±n/a nM |
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| Citation |  Mai, A; Massa, S; Rotili, D; Simeoni, S; Ragno, R; Botta, G; Nebbioso, A; Miceli, M; Altucci, L; Brosch, G Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J Med Chem49:6046-56 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase |
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| Name: | Histone deacetylase |
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| Synonyms: | Histone deacetylase HD1B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50930.01 |
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| Organism: | Zea mays |
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| Description: | ChEMBL_422128 |
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| Residue: | 458 |
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| Sequence: | MAASGEGVSLPSPAGGEDAHRRRVSYFYEPSIGDYYYGQGHPMKPHRIRMAHSLVVHYGL
HRLLELSRPYPASEADIRRFHSDDYVAFLASATGNPGVLDPRAIKRFNVGEDCPVFDGLF
PFCQASAGGSIGAAVKLNRGDADITVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKFH
RRVLYVDIDVHHGDGVEEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAAEGKHYALNVP
LSDGIDDTTFRGLFQCIIKKVMEVYQPDVVVLQCGADSLAGDRLGCFNLSVKGHADCLRF
LRSYNVPMMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLPYNDYYEYFGPDYTLHIQP
KSVENLNTTKDLENIKNMILENLSKIEHVPSTQFHDRPSDPEAPEEKEEDMDKRPPQRSR
LWSGGAYDSDTEDPDSLKSEGKDVTANFQMKDEPKDDL
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| BDBM50195618 |
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| n/a |
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| Name | BDBM50195618 |
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| Synonyms: | CHEMBL217192 | N-hydroxy-6-(3,4-dihydro-4-oxo-6-(1-phenyl-1-methoxymethyl)-2-pyrimidinylthio) hexanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N3O4S |
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| Mol. Mass. | 377.458 |
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| SMILES | COC(c1ccccc1)c1cc(=O)[nH]c(SCCCCCC(=O)NO)n1 |
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| Structure | 
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