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TargetProtein-glutamine gamma-glutamyltransferase 2
LigandBDBM50608198
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2273186
Ki 2300±n/a nM
Citation Cundy, NJArciszewski, JGates, EWJActon, SLPassley, KDAwoonor-Williams, EBoyd, EKXu, NPierson, ÉFernandez-Ansieta, CAlbert, MRMcNeil, NMRAdhikary, GEckert, RLKeillor, JW Novel irreversible peptidic inhibitors of transglutaminase 2. RSC Med Chem14:378-385 (2023) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Protein-glutamine gamma-glutamyltransferase 2
Name:Protein-glutamine gamma-glutamyltransferase 2
Synonyms:Protein-glutamine gamma-glutamyltransferase | Protein-glutamine gamma-glutamyltransferase 2 (TG2) | TGM2 | TGM2_HUMAN | Tissue transglutaminase | Tissue transglutaminase (TG2) | Transglutaminase 2 (TGM2) | Transglutaminase C | Transglutaminase-2
Type:Protein
Mol. Mass.:77309.30
Organism:Homo sapiens (Human)
Description:P21980
Residue:687
Sequence:
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50608198
n/a
NameBDBM50608198
Synonyms:CHEMBL5279745
TypeSmall organic molecule
Emp. Form.C35H41N5O6
Mol. Mass.627.7299
SMILESC[C@H](NC(=O)c1cccc2ccccc12)C(=O)N1CCN(CC1)C(=O)[C@H](CCCCNC(=O)C=C)NC(=O)OCc1ccccc1 |r|
Structure
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