| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein argonaute-2 |
|---|
| Ligand | BDBM50179360 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2273770 |
|---|
| IC50 | 690±n/a nM |
|---|
| Citation |  Van Meter, EN; Onyango, JA; Teske, KA A review of currently identified small molecule modulators of microRNA function. Eur J Med Chem188:0 (2020) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein argonaute-2 |
|---|
| Name: | Protein argonaute-2 |
|---|
| Synonyms: | 3.1.26.n2 | AGO2 | AGO2_HUMAN | Argonaute RISC catalytic component 2 | Argonaute2 | EIF2C2 | Eukaryotic translation initiation factor 2C 2 | PAZ Piwi domain protein | PPD | Protein argonaute-2 | Protein slicer | eIF-2C 2 | eIF2C 2 | hAgo2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 97253.38 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_120111 |
|---|
| Residue: | 859 |
|---|
| Sequence: | MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRS
FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
TSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQ
ALAKAVQVHQDTLRTMYFA
|
|
|
|---|
| BDBM50179360 |
|---|
| n/a |
|---|
| Name | BDBM50179360 |
|---|
| Synonyms: | CHEMBL3040216 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C51H40N6O23S6 |
|---|
| Mol. Mass. | 1297.28 |
|---|
| SMILES | CC1=CCC(=C\C1=N\C(=O)C1=CC=C\C(C1)=N/C(=O)/N=C1/CC(=CC=C1)C(=O)\N=C1\CC(=CC=C1C)C(=O)\N=C1/CC=C(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C(=O)\N=C1/CC=C(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O |c:4,13,24,26,34,36,45,72,t:1,11| |
|---|
| Structure | 
|
|---|
Search and Browse
