| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2C adrenergic receptor |
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| Ligand | BDBM50196116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_406590 (CHEMBL907694) |
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| Ki | 9.2±n/a nM |
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| Citation |  Höglund, IP; Silver, S; Engström, MT; Salo, H; Tauber, A; Kyyrönen, HK; Saarenketo, P; Hoffrén, AM; Kokko, K; Pohjanoksa, K; Sallinen, J; Savola, JM; Wurster, S; Kallatsa, OA Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem49:6351-63 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2C adrenergic receptor |
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| Name: | Alpha-2C adrenergic receptor |
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| Synonyms: | ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens] |
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| Type: | Enzyme |
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| Mol. Mass.: | 49552.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18825 |
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| Residue: | 462 |
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| Sequence: | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
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| BDBM50196116 |
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| n/a |
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| Name | BDBM50196116 |
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| Synonyms: | (R)-{4-[4-(3,4-dimethylpiperazin-1-yl)phenylamino]quinolin-3-yl}methanol | CHEMBL217542 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N4O |
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| Mol. Mass. | 362.468 |
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| SMILES | C[C@@H]1CN(CCN1C)c1ccc(Nc2c(CO)cnc3ccccc23)cc1 |
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| Structure | 
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