| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase I, thermostable |
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| Ligand | BDBM50196491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_432004 (CHEMBL918788) |
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| IC50 | 900±n/a nM |
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| Citation |  Sissi, C; Lucatello, L; Paul Krapcho, A; Maloney, DJ; Boxer, MB; Camarasa, MV; Pezzoni, G; Menta, E; Palumbo, M Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition. Bioorg Med Chem15:555-62 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase I, thermostable |
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| Name: | DNA polymerase I, thermostable |
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| Synonyms: | DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93906.95 |
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| Organism: | Thermus aquaticus |
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| Description: | ChEMBL_1289218 |
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| Residue: | 832 |
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| Sequence: | MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGD
AVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADD
VLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWA
DYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLK
LSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWP
PPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLA
LREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRL
EGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGH
PFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTK
LKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA
EEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYV
ETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARML
LQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
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| BDBM50196491 |
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| n/a |
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| Name | BDBM50196491 |
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| Synonyms: | 2,9-bis-(2-dimethylamino-ethyl)-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinoline-1,3,8,10-tetraone | CHEMBL225001 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H28N4O4 |
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| Mol. Mass. | 532.5891 |
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| SMILES | CN(C)CCn1c(=O)c2ccc3c4ccc5c6c(ccc(c7ccc(c2c37)c1=O)c46)c(=O)n(CCN(C)C)c5=O |
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| Structure | 
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