| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tau-tubulin kinase 1 |
|---|
| Ligand | BDBM50609143 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2276687 |
|---|
| IC50 | 98±n/a nM |
|---|
| Citation |  Halkina, T; Henderson, JL; Lin, EY; Himmelbauer, MK; Jones, JH; Nevalainen, M; Feng, J; King, K; Rooney, M; Johnson, JL; Marcotte, DJ; Chodaparambil, JV; Kumar, PR; Patterson, TA; Murugan, P; Schuman, E; Wong, L; Hesson, T; Lamore, S; Bao, C; Calhoun, M; Certo, H; Amaral, B; Dillon, GM; Gilfillan, R; de Turiso, FG Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem64:6358-6380 (2021) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tau-tubulin kinase 1 |
|---|
| Name: | Tau-tubulin kinase 1 |
|---|
| Synonyms: | BDTK | BDTK | Brain-derived tau kinase | KIAA1855 | TTBK1 | TTBK1_HUMAN | Tau-tubulin kinase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 142714.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_104387 |
|---|
| Residue: | 1321 |
|---|
| Sequence: | MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENV
ALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRS
QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA
RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR
KIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKER
GIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQ
GEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCV
EEEQSRGMGVPSSPVRAPPDSPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDL
PGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDS
KEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSM
QALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQ
RQVFSVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQV
PLAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGE
VLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVS
PGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSVLKSEPKPPGP
GAGLGAGTVTTGVGGVAVTSSPFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGEL
GLELASDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPAL
ADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWS
KRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAA
ALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGS
ATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESP
SPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGA
R
|
|
|
|---|
| BDBM50609143 |
|---|
| n/a |
|---|
| Name | BDBM50609143 |
|---|
| Synonyms: | CHEMBL5268795 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19N5O |
|---|
| Mol. Mass. | 333.3871 |
|---|
| SMILES | CC(C)(O)C#Cc1cc2n(cc(C3CC3)c2cn1)-c1ccnc(N)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
