| Reaction Details |
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 | Report a problem with these data |
| Target | Neurolysin, mitochondrial |
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| Ligand | BDBM50609215 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2277154 |
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| EC50 | 15700±n/a nM |
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| Citation |  Rahman, MS; Kumari, S; Esfahani, SH; Nozohouri, S; Jayaraman, S; Kinarivala, N; Kocot, J; Baez, A; Farris, D; Abbruscato, TJ; Karamyan, VT; Trippier, PC Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability. J Med Chem64:12705-12722 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neurolysin, mitochondrial |
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| Name: | Neurolysin, mitochondrial |
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| Synonyms: | 3.4.24.16 | MEP | Microsomal endopeptidase | Mitochondrial oligopeptidase M | NEUL_RAT | Neurotensin endopeptidase | Nln |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80252.04 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_120673 |
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| Residue: | 704 |
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| Sequence: | MITLCLSTLRGLHRAGGSRLQLTMTLGKELASPLQAMSSYTAAGRNVLRWDLSPEQIKTR
TEQLIAQTKQVYDTVGTIALKEVTYENCLQVLADIEVTYIVERTMLDFPQHVSSDREVRA
ASTEADKKLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHL
SEHIRNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDKYK
VTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKQENTAILQQLLPLRAQVAKLLGYNTHA
DFVLELNTAKSTSRVAAFLDDLSQKLKPLGEAEREFILSLKKKECEERGFEYDGKINAWD
LHYYMTQTEELKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVPDAHVWNKSVSL
YTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPV
AGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVD
SLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNATLDAASEY
AKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFKKEGIMNPE
VGMKYRNLILKPGGSLDGMDMLQNFLQREPNQKAFLMSRGLNGS
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| BDBM50609215 |
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| n/a |
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| Name | BDBM50609215 |
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| Synonyms: | CHEMBL5083819 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17F3N4O |
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| Mol. Mass. | 326.3169 |
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| SMILES | N[C@@H](Cc1c[nH]cn1)C(=O)NCCc1ccc(cc1)C(F)(F)F |r| |
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| Structure | 
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