| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50197000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453173 (CHEMBL902324) |
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| IC50 | 4510±n/a nM |
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| Citation |  Doppalapudi, VR; Tryder, N; Li, L; Aja, T; Griffith, D; Liao, FF; Roxas, G; Ramprasad, MP; Bradshaw, C; Barbas, CF Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies. Bioorg Med Chem Lett17:501-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49664.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
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| Residue: | 442 |
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| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50197000 |
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| n/a |
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| Name | BDBM50197000 |
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| Synonyms: | CHEMBL429019 | N-(35-{[4-(3,5-dioxohexyl)phenyl]carbamoyl}-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-yl)-N'-methyl-N'-{[5-(1,3-oxazol-2-yl)-2-{2-[(1,2-oxazol-5-yl)sulfamoyl]phenyl}phenyl]methyl}pentanediamide |
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| Type | Small organic molecule |
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| Emp. Form. | C62H86N6O20S |
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| Mol. Mass. | 1267.439 |
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| SMILES | CN(Cc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)-c1ncco1)C(=O)CCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc(CCC(=O)CC(C)=O)cc1 |
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| Structure | 
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