| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50197003 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453172 (CHEMBL902323) |
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| IC50 | 1.6±n/a nM |
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| Citation |  Doppalapudi, VR; Tryder, N; Li, L; Aja, T; Griffith, D; Liao, FF; Roxas, G; Ramprasad, MP; Bradshaw, C; Barbas, CF Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies. Bioorg Med Chem Lett17:501-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50197003 |
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| n/a |
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| Name | BDBM50197003 |
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| Synonyms: | CHEMBL241460 | N-[4-(3,5-dioxo-hexyl)-phenyl]-3-(2-{2-[2-({[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-methyl-carbamoyl}-methoxy)-ethoxy]-ethoxy}-ethoxy)-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C43H49N5O12S |
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| Mol. Mass. | 859.94 |
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| SMILES | CN(Cc1cc(ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)-c1ncco1)C(=O)COCCOCCOCCOCCC(=O)Nc1ccc(CCC(=O)CC(C)=O)cc1 |
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| Structure | 
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