| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM50610351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2280810 |
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| EC50 | 40±n/a nM |
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| Citation |  Hoshikawa, T; Watanabe, T; Kotake, M; Tiberghien, N; Woo, CK; Lewis, S; Briston, T; Koglin, M; Staddon, JM; Powney, B; Schapira, AHV; Takle, AK Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones. Bioorg Med Chem Lett81:0 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59724.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
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| Residue: | 536 |
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| Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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| BDBM50610351 |
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| n/a |
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| Name | BDBM50610351 |
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| Synonyms: | CHEMBL5272738 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24ClN5O |
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| Mol. Mass. | 385.89 |
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| SMILES | Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(Cl)cc1 |
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| Structure | 
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