Reaction Details |
| Report a problem with these data |
Target | Glycogen synthase kinase-3 beta |
---|
Ligand | BDBM50610404 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2280818 |
---|
IC50 | 3.0±n/a nM |
---|
Citation | Luo, G; Chen, L; Jacutin-Porte, S; Han, Y; Burton, CR; Xiao, H; Krause, CM; Cao, Y; Liu, N; Kish, K; Lewis, HA; Macor, JE; Dubowchik, GM Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors. Bioorg Med Chem Lett81:0 (2023) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Glycogen synthase kinase-3 beta |
---|
Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
|
|
|
BDBM50610404 |
---|
n/a |
---|
Name | BDBM50610404 |
Synonyms: | CHEMBL5266186 |
Type | Small organic molecule |
Emp. Form. | C21H17FN4O2 |
Mol. Mass. | 376.3837 |
SMILES | Fc1ccccc1-c1cncc(NC(=O)c2ccnc(NC(=O)C3CC3)c2)c1 |
Structure |
|