| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
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| Ligand | BDBM50197858 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_437626 (CHEMBL905986) |
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| IC50 | 45000±n/a nM |
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| Citation |  Garzya, V; Forbes, IT; Gribble, AD; Hadley, MS; Lightfoot, AP; Payne, AH; Smith, AB; Douglas, SE; Cooper, DG; Stansfield, IG; Meeson, M; Dodds, EE; Jones, DN; Wood, M; Reavill, C; Scorer, CA; Worby, A; Riley, G; Eddershaw, P; Ioannou, C; Donati, D; Hagan, JJ; Ratti, EA Studies towards the identification of a new generation of atypical antipsychotic agents. Bioorg Med Chem Lett17:400-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C9 |
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| Name: | Cytochrome P450 2C9 |
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| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 55636.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11712 |
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| Residue: | 490 |
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| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
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| BDBM50197858 |
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| n/a |
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| Name | BDBM50197858 |
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| Synonyms: | 4'-chloro-biphenyl-4-sulfonic acid (3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide | CHEMBL231430 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23ClN2O2S |
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| Mol. Mass. | 426.959 |
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| SMILES | CN1CCc2ccc(NS(=O)(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1 |
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| Structure | 
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