| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM50610873 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2282296 |
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| IC50 | 7.1±n/a nM |
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| Citation |  Petrov, SA; Zyk, NY; Machulkin, AE; Beloglazkina, EK; Majouga, AG PSMA-targeted low-molecular double conjugates for diagnostics and therapy. Eur J Med Chem225:0 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84333.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1497035 |
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| Residue: | 750 |
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| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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| BDBM50610873 |
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| n/a |
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| Name | BDBM50610873 |
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| Synonyms: | CHEMBL5277672 |
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| Type | Small organic molecule |
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| Emp. Form. | C62H96FN11O26Si |
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| Mol. Mass. | 1458.5676 |
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| SMILES | [#6]C([#6])([#6])[Si;v4](F)(c1ccc(cc1)-[#6](=O)-[#7]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6]-[#6](-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6](-[#8])=O)-[#6]-[#6]-[#7](-[#6]-[#6](-[#8])=O)-[#6]-[#6]-[#7](-[#6]-[#6](-[#8])=O)-[#6]-[#6]-1)-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#8]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](-[#8])=O)-[#6](-[#8])=O)-[#6](-[#8])=O)-[#6](-[#8])=O)C([#6])([#6])[#6] |r| |
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| Structure | 
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