Reaction Details |
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Target | Tyrosine-protein kinase Lyn |
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Ligand | BDBM50161162 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2282343 |
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IC50 | 4400±n/a nM |
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Citation | Liu, XJ; Xu-Liu, na; Pang, XJ; -Ying Yuan, X; Yu, GX; Li, YR; Guan, YF; Zhang, YB; Song, J; Zhang, QR; Zhang, SY Progress in the development of small molecular inhibitors of the Bruton's tyrosine kinase (BTK) as a promising cancer therapy. Bioorg Med Chem47:0 (2021) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lyn |
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Name: | Tyrosine-protein kinase Lyn |
Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
Type: | Protein |
Mol. Mass.: | 58575.92 |
Organism: | Homo sapiens (Human) |
Description: | P07948 |
Residue: | 512 |
Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
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BDBM50161162 |
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n/a |
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Name | BDBM50161162 |
Synonyms: | AVL-292 | CC-292 | Spebrutinib | US10596172, Compound I-182 | US10828300, Compound I-182 | US11351168, Compound I-182 | US9987276, Compound I-182 |
Type | Small organic molecule |
Emp. Form. | C22H22FN5O3 |
Mol. Mass. | 423.4402 |
SMILES | COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NC(=O)C=C)c3)n2)cc1 |
Structure |
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