| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
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| Ligand | BDBM50610950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2282705 |
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| IC50 | 21650±n/a nM |
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| Citation |  Zerio, CJ; Cunningham, TA; Tulino, AS; Alimusa, EA; Buckley, TM; Moore, KT; Dodson, M; Wilson, NC; Ambrose, AJ; Shi, T; Sivinski, J; Essegian, DJ; Zhang, DD; Schürer, SC; Schatz, JH; Chapman, E Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action. J Med Chem64:15727-15746 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-I |
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| Name: | Eukaryotic initiation factor 4A-I |
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| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46146.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864983 |
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| Residue: | 406 |
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| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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| BDBM50610950 |
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| n/a |
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| Name | BDBM50610950 |
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| Synonyms: | CHEMBL5277447 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20ClNO3 |
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| Mol. Mass. | 405.874 |
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| SMILES | CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2ccc(Cl)cc2n1 |
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| Structure | 
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