Ki Summary

Reaction Details

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Target

LIM domain kinase 2

Ligand

BDBM50611814

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2284269

IC50

<0.100000±n/a nM

Citation

Manetti, F Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem155:445-458 (2018) [PubMed]

More Info.:

Get all data from this article, Assay Method

LIM domain kinase 2

Name:

LIM domain kinase 2

Synonyms:

LIMK2 | LIMK2_HUMAN

Type:

PROTEIN

Mol. Mass.:

72238.81

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1514398

Residue:

638

Sequence:

MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP

BDBM50611814

n/a

Name

BDBM50611814

Synonyms:

CHEMBL3799932

Type

Small organic molecule

Emp. Form.

C25H30N6O3

Mol. Mass.

462.5441

SMILES

COC(=O)Cc1cccc(NC(=O)C2(CN)CCN(CC2)c2ncnc3[nH]c4CCCc4c23)c1

Structure