| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50311245 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2284568 |
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| Ki | 6.0±n/a nM |
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| Citation |  Rocha, DA; Silva, EB; Fortes, IS; Lopes, MS; Ferreira, RS; Andrade, SF Synthesis and structure-activity relationship studies of cruzain and rhodesain inhibitors. Eur J Med Chem157:1426-1459 (2018) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50311245 |
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| n/a |
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| Name | BDBM50311245 |
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| Synonyms: | (S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)thiazole-5-carboxamide | CHEMBL1078675 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26N2O3S2 |
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| Mol. Mass. | 502.648 |
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| SMILES | Cc1nc(sc1C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1)-c1ccccc1 |r| |
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| Structure | 
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