Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50612777 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2289798 |
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Ki | 14±n/a nM |
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Citation | Tolentino, KT; Mashinson, V; Sharma, MK; Chhonker, YS; Murry, DJ; Hopkins, CR From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of ?1 modulators. Eur J Med Chem244:0 (2022) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50612777 |
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n/a |
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Name | BDBM50612777 |
Synonyms: | CHEMBL5288366 |
Type | Small organic molecule |
Emp. Form. | C23H26ClF2N3O |
Mol. Mass. | 433.922 |
SMILES | Cc1c(Cl)cccc1NC(=O)CN1CCC2(CCCN2Cc2ccc(F)c(F)c2)C1 |
Structure |
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