| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50612779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2289798 |
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| Ki | 27±n/a nM |
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| Citation |  Tolentino, KT; Mashinson, V; Sharma, MK; Chhonker, YS; Murry, DJ; Hopkins, CR From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of ?1 modulators. Eur J Med Chem244:0 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM50612779 |
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| n/a |
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| Name | BDBM50612779 |
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| Synonyms: | CHEMBL5272393 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28F3N3O |
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| Mol. Mass. | 431.4938 |
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| SMILES | Cc1cc(NC(=O)CN2CCC3(CCCN3Cc3ccc(F)c(F)c3)CC2)ccc1F |
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| Structure | 
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