| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase ULK1 |
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| Ligand | BDBM50612790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2289887 |
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| IC50 | 31±n/a nM |
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| Citation |  Ye, W; Fan, C; Fu, K; Wang, X; Lin, J; Nian, S; Liu, C; Zhou, W The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance. Eur J Med Chem244:0 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase ULK1 |
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| Name: | Serine/threonine-protein kinase ULK1 |
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| Synonyms: | ATG1 | Autophagy-related protein 1 homolog | KIAA0722 | ULK1 | ULK1_HUMAN | Unc-51-like kinase 1 | hATG1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 112661.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1510275 |
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| Residue: | 1050 |
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| Sequence: | MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS
GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP
FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP
PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA
PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR
NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT
LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL
QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG
SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEH
TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL
VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF
FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM
LSDQADIENVTKCKLCIERRLSALLTGICA
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| BDBM50612790 |
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| n/a |
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| Name | BDBM50612790 |
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| Synonyms: | CHEMBL5276694 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N8 |
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| Mol. Mass. | 396.4478 |
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| SMILES | C1CC(C1)c1cc(Nc2nc(Nc3ccc4[nH]ncc4c3)nc3ccccc23)n[nH]1 |
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| Structure | 
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