| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Ligand | BDBM246383 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2290898 |
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| IC50 | 81±n/a nM |
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| Citation |  Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem66:4106-4130 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
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| Type: | Enzyme |
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| Mol. Mass.: | 69222.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y463 |
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| Residue: | 629 |
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| Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
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| BDBM246383 |
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| n/a |
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| Name | BDBM246383 |
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| Synonyms: | US9446044, 69 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14FN5O2S |
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| Mol. Mass. | 383.399 |
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| SMILES | COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 |
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| Structure | 
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