| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Ligand | BDBM50567047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2290901 |
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| IC50 | 9593±n/a nM |
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| Citation |  Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem66:4106-4130 (2023) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Synonyms: | DYRK4 | DYRK4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59629.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1475744 |
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| Residue: | 520 |
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| Sequence: | MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
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| BDBM50567047 |
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| n/a |
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| Name | BDBM50567047 |
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| Synonyms: | CHEMBL4848254 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N6 |
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| Mol. Mass. | 240.2639 |
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| SMILES | CN(C)c1nccc(n1)-c1cnn2ncccc12 |
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| Structure | 
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