| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Ligand | BDBM50583755 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2290911 |
|---|
| Kd | 0.086000±n/a nM |
|---|
| Citation |  Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem66:4106-4130 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85616.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13627 |
|---|
| Residue: | 763 |
|---|
| Sequence: | MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
|
|
|
|---|
| BDBM50583755 |
|---|
| n/a |
|---|
| Name | BDBM50583755 |
|---|
| Synonyms: | CHEMBL5070553 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H13F3N6 |
|---|
| Mol. Mass. | 322.2884 |
|---|
| SMILES | Cc1nc2ccc(nc2n1CC(F)(F)F)-c1cc(N)nc(N)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
