| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek4 |
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| Ligand | BDBM50613381 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2292067 |
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| IC50 | 80±n/a nM |
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| Citation |  Wells, CI; Kapadia, NR; Couņago, RM; Drewry, DH In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases. Medchemcomm9:44-66 (2018) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek4 |
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| Name: | Serine/threonine-protein kinase Nek4 |
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| Synonyms: | NEK kinase | NEK4 | NEK4_HUMAN | STK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 94610.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774384 |
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| Residue: | 841 |
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| Sequence: | MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL
KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ
YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN
KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT
MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE
SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA
TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ
PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG
SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR
REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS
RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL
SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS
KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE
VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN
F
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| BDBM50613381 |
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| n/a |
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| Name | BDBM50613381 |
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| Synonyms: | CHEMBL5278787 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N3O |
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| Mol. Mass. | 317.3844 |
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| SMILES | NC[C@@H](NC(=O)c1ccc(cc1)-c1ccncc1)c1ccccc1 |r| |
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| Structure | 
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