| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Srms |
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| Ligand | BDBM50613392 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2292229 |
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| IC50 | >2000±n/a nM |
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| Citation |  Luo, G; Chen, L; Burton, CR; Xiao, H; Sivaprakasam, P; Krause, CM; Cao, Y; Liu, N; Lippy, J; Clarke, WJ; Snow, K; Raybon, J; Arora, V; Pokross, M; Kish, K; Lewis, HA; Langley, DR; Macor, JE; Dubowchik, GM Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J Med Chem59:1041-51 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Srms |
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| Name: | Tyrosine-protein kinase Srms |
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| Synonyms: | C20orf148 | SRC | SRMS | SRMS_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54517.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_18250298 |
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| Residue: | 488 |
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| Sequence: | MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY
DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW
YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY
LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY
FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI
VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD
GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF
TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL
HAIHRCHP
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| BDBM50613392 |
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| n/a |
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| Name | BDBM50613392 |
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| Synonyms: | CHEMBL5270581 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4O2 |
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| Mol. Mass. | 358.3932 |
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| SMILES | O=C(Nc1cc(ccn1)C(=O)Nc1cnccc1-c1ccccc1)C1CC1 |
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| Structure | 
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