Reaction Details |
| Report a problem with these data |
Target | Golgi-associated PDZ and coiled-coil motif-containing protein |
---|
Ligand | BDBM50613394 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2292243 |
---|
IC50 | >2000±n/a nM |
---|
Citation | Luo, G; Chen, L; Burton, CR; Xiao, H; Sivaprakasam, P; Krause, CM; Cao, Y; Liu, N; Lippy, J; Clarke, WJ; Snow, K; Raybon, J; Arora, V; Pokross, M; Kish, K; Lewis, HA; Langley, DR; Macor, JE; Dubowchik, GM Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J Med Chem59:1041-51 (2016) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Golgi-associated PDZ and coiled-coil motif-containing protein |
---|
Name: | Golgi-associated PDZ and coiled-coil motif-containing protein |
Synonyms: | CAL | CFTR-associated ligand | FIG | Fused in glioblastoma | GOPC | GOPC_HUMAN | Golgi-associated PDZ and coiled-coil motif-containing protein | PDZ protein interacting specifically with TC10 | PIST |
Type: | PROTEIN |
Mol. Mass.: | 50511.32 |
Organism: | Homo sapiens |
Description: | ChEMBL_117103 |
Residue: | 462 |
Sequence: | MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
|
|
|
BDBM50613394 |
---|
n/a |
---|
Name | BDBM50613394 |
Synonyms: | CHEMBL5278465 |
Type | Small organic molecule |
Emp. Form. | C21H17ClN4O2 |
Mol. Mass. | 392.838 |
SMILES | Clc1ccc(cc1)-c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 |
Structure |
|