| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-6 |
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| Ligand | BDBM50200306 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_408843 (CHEMBL909967) |
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| IC50 | >500000±n/a nM |
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| Citation |  Kopka, K; Faust, A; Keul, P; Wagner, S; Breyholz, HJ; Höltke, C; Schober, O; Schäfers, M; Levkau, B 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis. J Med Chem49:6704-15 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-6 |
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| Name: | Caspase-6 |
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| Synonyms: | Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 33312.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55212 |
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| Residue: | 293 |
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| Sequence: | MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
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| BDBM50200306 |
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| n/a |
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| Name | BDBM50200306 |
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| Synonyms: | (S)-1-(4-iodobenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin | CHEMBL217457 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21IN2O5S |
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| Mol. Mass. | 540.371 |
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| SMILES | COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(Cc3ccc(I)cc3)C(=O)C(=O)c2c1 |
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| Structure | 
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