| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 2 |
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| Ligand | BDBM50200395 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_453666 (CHEMBL885667) |
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| IC50 | 169800±n/a nM |
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| Citation |  An, S; Park, YD; Paik, YK; Jeong, TS; Lee, WS Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon. Bioorg Med Chem Lett17:1112-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 2 |
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| Name: | Sterol O-acyltransferase 2 |
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| Synonyms: | ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 59912.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75908 |
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| Residue: | 522 |
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| Sequence: | MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
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| BDBM50200395 |
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| n/a |
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| Name | BDBM50200395 |
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| Synonyms: | (R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl 3-hydroxy-3-methylbutanoate | 3'-Hydroxyisovalerylshikonin | CHEMBL397309 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24O7 |
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| Mol. Mass. | 388.4111 |
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| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]=[#6](-[#8]-[#6](=O)-[#6]C([#6])([#6])[#8])-c1cc(-[#8])c2c(-[#8])ccc(-[#8])c2c1-[#8] |w:4.3| |
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| Structure | 
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