| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 7 |
|---|
| Ligand | BDBM50614234 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2296131 |
|---|
| EC50 | 6.0±n/a nM |
|---|
| Citation |  Dickson, L; Teall, M; Chevalier, E; Cheung, T; Liwicki, GM; Mack, S; Stephenson, A; White, K; Fosbeary, R; Harrison, DC; Brice, NL; Doyle, K; Ciccocioppo, R; Wu, C; Almond, S; Patel, TR; Mitchell, P; Barnes, M; Ayscough, AP; Dawson, LA; Carlton, M; Bürli, RW Discovery of ACS Med Chem Lett14:442-449 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 7 |
|---|
| Name: | Metabotropic glutamate receptor 7 |
|---|
| Synonyms: | GPRC1G | GRM7 | GRM7 protein | GRM7_HUMAN | MGLUR7 | Metabotropic glutamate receptor 7 | metabotropic glutamate 7 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 102262.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14831 |
|---|
| Residue: | 915 |
|---|
| Sequence: | MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
|
|
|
|---|
| BDBM50614234 |
|---|
| n/a |
|---|
| Name | BDBM50614234 |
|---|
| Synonyms: | CHEMBL5285249 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20FNO3S |
|---|
| Mol. Mass. | 361.43 |
|---|
| SMILES | C[C@H](C(=O)N[C@@H]1Cc2ccccc2[C@H]1S(C)(=O)=O)c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
