| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-3 |
|---|
| Ligand | BDBM50200931 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_423899 (CHEMBL913573) |
|---|
| Ki | 1500±n/a nM |
|---|
| Citation |  Henzing, AJ; Dodson, H; Reid, JM; Kaufmann, SH; Baxter, RL; Earnshaw, WC Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo. J Med Chem49:7636-45 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-3 |
|---|
| Name: | Caspase-3 |
|---|
| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
|---|
| Type: | Hydrolase; heterotetramer of two heterodimers |
|---|
| Mol. Mass.: | 31607.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 277 |
|---|
| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
|
|
|
|---|
| BDBM50200931 |
|---|
| n/a |
|---|
| Name | BDBM50200931 |
|---|
| Synonyms: | 2,6-dimethyl-benzoic acid (S)-3-{(S)-2-((S)-2-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-[2-imino-5-((3aS,4S,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoylamino}-4-carboxy-2-oxo-butylester | CHEMBL415844 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H55N7O13S |
|---|
| Mol. Mass. | 910.001 |
|---|
| SMILES | Cc1cccc(C)c1C(=O)OCC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C(=N)CCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NC(=O)[C@H](CCC(O)=O)NC(=O)OCc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
