| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase 2, mitochondrial |
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| Ligand | BDBM50200991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422916 (CHEMBL908767) |
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| IC50 | 23000±n/a nM |
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| Citation |  Hernandez, AI; Familiar, O; Negri, A; Rodríguez-Barrios, F; Gago, F; Karlsson, A; Camarasa, MJ; Balzarini, J; Pérez-Pérez, MJ N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem49:7766-73 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase 2, mitochondrial |
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| Name: | Thymidine kinase 2, mitochondrial |
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| Synonyms: | KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31013.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1333885 |
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| Residue: | 265 |
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| Sequence: | MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
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| BDBM50200991 |
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| n/a |
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| Name | BDBM50200991 |
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| Synonyms: | 1-[2-[2-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]ethoxy]ethyl]thymine | CHEMBL219510 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N3O4 |
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| Mol. Mass. | 457.521 |
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| SMILES | Cc1cn(CCOCCOC(c2ccccc2)(c2ccccc2)c2ccncc2)c(=O)[nH]c1=O |
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| Structure | 
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